1. (v. t.) To destroy the organic texture and vital functions of; to produce gangrene in.

2. (v. t.) To destroy the active powers or essential qualities of; to change by chemical action.

3. (v. t.) To deaden by religious or other discipline, as the carnal affections, bodily appetites, or worldly desires; to bring into subjection; to abase; to humble.

4. (v. t.) To affect with vexation, chagrin, or humiliation; to humble; to depress.

5. (v. i.) To lose vitality and organic structure, as flesh of a living body; to gangrene.

6. (v. i.) To practice penance from religious motives; to deaden desires by religious discipline.

7. (v. i.) To be subdued; to decay, as appetites, desires, etc.