1. (n.) The farthest or remotest part; as, the extremities of a country.

2. (n.) One of locomotive appendages of an animal; a limb; a leg or an arm of man.

3. (n.) The utmost point; highest degree; most aggravated or intense form.

4. (n.) The highest degree of inconvenience, pain, or suffering; greatest need or peril; extreme need; necessity.