1. (prep.) In spite of; notwithstanding; against, or in defiance of; as, despite his prejudices.

2. (n.) Malice; malignity; spite; malicious anger; contemptuous hate.

3. (n.) An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.

4. (n.) To vex; to annoy; to offend contemptuously.